Faculty

The CR-PSOC is uniquely well positioned to support this mission through its diverse team of 12 physical scientists and 8 cancer researchers from fields encompassing physics, chemistry, biomedical engineering, biophysics, biochemistry, pharmacology, and hematology-oncology.  The proposed Center will be led by a pair of Northwestern researchers: renowned physical scientist, Thomas O’Halloran in the role of Contact Principal Investigator, and internationally recognized cancer researcher, Jonathan D. Licht, MD, complementing him in a multi-leadership model in the role of PD/PI.  They will be supported by a team of researchers from the Chicago region’s premier research institutions: Northwestern University (NU), the University of Chicago (UoC) and University of Illinois at Chicago (UIC).  The Center’s project leaders recruited additional thought leaders in the physical sciences and chromatin fields from outside Chicago, namely  MIT, Memorial-Sloan Kettering Cancer Center, and the University of Massachusetts Medical School. 

UNIT

PROJECT TITLE

PROJECT TEAM*

DEPARTMENTAL AFFILIATION

INSTITUTION

Administrative Core

Contact PI

Thomas O’Halloran

Chemistry

Northwestern

PI/PD

Jonathan Licht

Medicine/Heme-Onc

Northwestern

Center Administrator

Sheila Judge

Chemistry of Life Processes Institute

Northwestern

Patient Advocate

Stuart Cornew

 

 

Project 1

 

Chemical Biology Approaches

Ionic modulation of chromatin in cancer

Thomas  O’Halloran

Chemistry

Northwestern

Andrew Mazar

Molecular Bioscience

Northwestern

Vadim Backman

Biomedical Engineering

Northwestern

Igal Szleifer

Biomedical Engineering

Northwestern

Jack Kaplan

Biochemistry and Molecular Genetics

Univ. of Illinois-Chicago

Ming Zhao

Medicine

Northwestern

John Marko

Molecular Biosci./Physics

Northwestern

Navdeep Chandel

Medicine

Northwestern

Project 2

 

Genetic Approaches

Molecular modulation of chromatin and nuclear structure in cancer

Jonathan Licht

Medicine/Heme-Onc

Northwestern

Chuan He

Chemistry

Univ. of Chicago

Ross Levine

Medicine

MSKCC

Job Dekker

Biochemistry/ Mol. Pharmacol.

Univ. Mass. Med. School

Lucy A. Godley

Medicine

Univ. of Chicago

Project 3

 

Biophysical Approaches

Mechanics of nuclei, chromosomes and chromatin in cancer

John Marko

Molecular Bioscience/ Physics & Astronomy

Northwestern

John Crispino

Medicine/Heme-Onc

Northwestern

Leonid Mirny

Health Sciences Technology/ Physics

MIT

Robert Goldman

Cell and Molecular Biology

Northwestern

Vadim Backman

Biomedical Engineering

Northwestern

Igal Szleifer

Biomedical Engineering

Northwestern

Adilson Motter

Physics & Astronomy

Northwestern

Cores

PDX Tumor Core

Andrew Mazar

Molecular Bioscience

Northwestern

Nanocytometry Core

Vadim Backman

Biomedical Engineering

Northwestern

Education & Outreach Unit

Sheila Judge

Chemistry of Life Processes Institute

Northwestern

Benette Phillips

Lurie Cancer Center

Northwestern